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Erm N-methyl transferase methylation of A2058 leads to resistance to lincosamide, macrolide, and streptogramin B, but not to resistance to ketolides, which are a subclass of macrolides

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The first signal in this activation process seems to rely on the production of mitochondrial reactive oxygen species (ROS) and the upregulation of NLRP3 expression through signaling pathways involving Toll-like receptors (TLR) and myeloid differentiation response (MyD88) nuclear factors κB (NF-κB) (13)

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